The picture below shows that students with higher anxiety scores are more likely to have lower levels of amygdala activation when viewing photographs of 'happy faces.' Of interest too, the higher anxiety subjects were still within normal ranges of personality.

Gifted children may also especially prone to existential depression, and studies of gifted children have shown that gifted students may react more intensely than average-ability students to frustration. Studies of stress and burn-out in gifted students suggest that key factors can be an inappropriate level of intellectual stimulation ('underload' or 'overload' as Hoekman et al. have recently commented).
One helpful book offering a step-by-step program to improve a child's optimism is Dr. Seligman's The Optimistic Child
Seligman's Optimism Program
Happy Faces fMRI
Optimism article
Hoekman, McCormick, Barnett, 2005. The Important Role of Optimism in a Motivational Investigation of the Education of Gifted Adolescents, Gifted Child Quarterly, Spring 2005 (not online).
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